(£) GBP (Default)
  • ($) USD
  • (€) EUR
  • ($) AUD
  • ($) CAD
  • ($) NZD
Pharma Lab Global

15% off first order with code: 1storder

Pharma Lab Global
99%+ Quality Guaranteed
Pharma Lab Global

Competitive Prices

Pharma Lab Global
Shipping Protection
Pharma Lab Global
Fast Order Process
Unveiling the Protective Power of NAD+ Against Alzheimer’s Disease
NAD+ against Alzheimer's
Table of Contents

Fighting Alzheimer’s Disease with NAD+ New Zealand

Alzheimer’s disease is a debilitating neurodegenerative condition that affects millions of people worldwide. As researchers continue to search for effective treatments, NAD+ (nicotinamide adenine dinucleotide) has emerged as a promising molecule with the potential to protect against Alzheimer’s. This blog will explore the protective power of NAD+ against Alzheimer’s by playing a vital role in reducing oxidative stress, supporting neuronal health, and enhancing DNA repair, all of which are essential for preventing or slowing the progression of Alzheimer’s disease.

What is Alzheimer’s Disease?

Alzheimer’s disease is a progressive neurological disorder that primarily affects memory, thinking, and behaviour. Alzheimer’s dementia is becoming more common among the elderly. Early symptoms include memory impairment with the difficulty remembering recent events and confusion, which gradually worsen over time. As the disease advances, individuals may experience severe memory loss, disorientation, and challenges in communicating and performing daily activities. Behavioural changes such as mood swings, depression, and social withdrawal are also common.

The exact causes of Alzheimer’s disease are not fully understood, but it is believed to result from a combination of genetic, environmental, and lifestyle factors. The disease is characterized by the accumulation of amyloid plaques and tau tangles in the brain, which disrupts cell function and leads to neuron death. Alzheimer’s has a profound impact on individuals, often requiring full-time care and significantly affecting the emotional and financial well-being of families. Despite ongoing New Zealand research, there is currently no cure for Alzheimer’s disease.

What is NAD+?

NAD+, or Nicotinamide Adenine Dinucleotide, is a coenzyme found in every living cell and plays a critical role in cellular metabolism. Variations of NAD+ are also known as nicotinamide adenine dinucleotide; NMN, nicotinamide mononucleotide; NAM, nicotinamide; NA, nicotinic acid. It is involved in many biological processes, including energy metabolism, DNA repair, cell survival, and the regulation of circadian rhythms. NAD+ is integral to oxidation-reduction reactions, the processes that help to convert nutrients into energy. With its pivotal role in multiple cellular functions, NAD+ has become a prominent subject of research in the scientific community. Pharma Lab Global New Zealand currently offers differing mg of NAD+ learn more here.

Oxidative Stress

Oxidative stress occurs when there is an imbalance between free radicals and antioxidants in the body, leading to cellular damage and degeneration of organs. In the brain, oxidative stress can damage neurons, contributing to the development of Alzheimer’s which is the most common cause of dementia. NAD+ is a vital coenzyme that have positive effects and help regulate oxidative stress by participating in redox reactions that neutralize harmful free radicals. By maintaining a balanced oxidative state, NAD+ helps protect neurons from damage and preserves their functionality demonstrated by previous study.

Supporting Neuronal Health

Investigating the power of NAD+ against Alzheimer's
Investigating the power of NAD+ against Alzheimer’s

Neurons are the primary cells affected by Alzheimer’s disease and vascular dementia, and maintaining their health is critical for preventing the condition. NAD+ supports neuronal health in several ways. Firstly, it enhances mitochondrial function, ensuring that neurons have a sufficient supply of ATP (adenosine triphosphate), the energy currency of the cell, which could be a cause of Parkinson’s Disease. Secondly, NAD+ promotes the repair of damaged cells by activating sirtuins, a family of proteins involved in cellular repair and longevity. These mechanisms help sustain neuronal function and prevent the loss of cognitive abilities including memory and spatial learning associated with Alzheimer’s.

Enhancing DNA Repair

DNA damage is a significant factor in the aging process and the development of neurodegenerative diseases like Alzheimer’s. NAD+ plays a crucial role in DNA repair by activating PARPs (poly ADP-ribose polymerases), enzymes that detect and repair damaged DNA strands. By enhancing DNA repair, scientists have found that NAD treatment can help prevent the accumulation of genetic mutations that can lead to cellular dysfunction and neurodegeneration. This protective effect is particularly important in the brain, where the high metabolic activity makes neurons more susceptible to DNA damage.

The Protection of NAD+ Against Alzheimer’s: Recent Research & Studies

Recent studies have highlighted the potential of the power of NAD+ against Alzheimer’s disease. Research has shown that boosting NAD+ levels in animal models of Alzheimer’s can improve cognitive function and reduce the pathological hallmarks of the disease, such as amyloid-beta plaques and tau tangles. These findings suggest that the benefits of supplementation with NAD+ against Alzheimer’s could be a viable strategy for preventing or slowing the progression of Alzheimer’s in humans. Additionally, clinical trials are underway to investigate the safety and efficacy of NAD+ precursor supplementation in Alzheimer’s patients, bringing hope for new therapeutic options.

Another peptide paving the way for a treatment for Alzheimer’s Disease is Vasoactive Intestinal Peptide (VIP) shows promise as a potential therapeutic agent due to its neuroprotective and anti-inflammatory properties. VIP helps regulate immune responses, reducing harmful inflammation in the brain, which plays a significant role in Alzheimer’s progression. Additionally, it supports cognitive functions by promoting healthy neural activity and protecting brain cells from damage. New Zealand Studies suggest that VIP’s ability to modulate signalling in the central nervous system could slow disease progression and improve memory and cognitive performance. Furthermore, there is some evidence to suggest that VIP peptide can improve blood flow which could prove useful for the treatment of vascular dementia. While further research is needed, VIP’s multifaceted benefits make it a hopeful candidate for making a significant difference when treating Alzheimer’s and similar neurodegenerative diseases.

Conclusion

NAD+ is a powerful molecule with the potential to protect against Alzheimer’s disease by reducing oxidative stress, supporting neuronal health, and enhancing DNA repair. As research continues to uncover the benefits of NAD+ against Alzheimer’s, it holds promise as a therapeutic agent in the fight against cognitive health and neurodegenerative diseases. By understanding and harnessing the protective power of NAD infusion and treatments, we can take significant steps toward preventing and managing Alzheimer’s, offering hope to millions affected by this devastating condition. A new and emerging peptide, P-21 and its effect on neurological disorders is discussed in our blog.

Buy NAD+ Online New Zealand

Pharma Lab Global New Zealand is one of the best locations to purchase high purity NAD+ for research purposes. Pharma Lab Global is a trusted supplier of research peptides worldwide.

References:

[1] Orr ME, Kotkowski E, Ramirez P, Bair-Kelps D, Liu Q, Brenner C, Schmidt MS, Fox PT, Larbi A, Tan C, Wong G, Gelfond J, Frost B, Espinoza S, Musi N, Powers B. A randomized placebo-controlled trial of nicotinamide riboside in older adults with mild cognitive impairment. Geroscience. 2024 Feb;46(1):665-682.

[2] Campbell JM. Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts. Nutrients. 2022 Aug 7;14(15):3231.

[3] Radenkovic, D.; Reason; Verdin, E. Clinical Evidence for Targeting NAD Therapeutically. Pharmaceuticals 2020, 13, 247.


ALL PRODUCT INFORMATION AND ARTICLES ON THIS SITE ARE FOR EDUCATIONAL PURPOSES ONLY

DISCLAIMER: All products sold by Pharma Lab Global are for research and laboratory use only. These products are not designed for use or consumption by humans or animals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such. By purchasing from our Website the buyer accepts and acknowledges the risks involved with handling of these products. All articles and product information provided on this Website are for informational and educational purposes only. Handling and use of these products should be restricted to suitably qualified professionals.

Related Articles